Cocaine addiction isn’t simply a failure of willpower — it’s the result of lasting biological changes in the brain.

Scientists identify the protein DeltaFosB as the "master switch" that rewires the brain's memory and reward circuits, driving chronic cocaine addiction and relapse.

People taking GLP-1 drugs often talk about “food noise” vanishing: the constant mental chatter about food that dominated thei ...

When considering the drugs most likely to cause former addicts to repeatedly relapse, opioids, cocaine, and methamphetamine ...

Researchers have used mouse models to study how cocaine addiction alters the brain, illuminating why relapse is common as ...

Weight-loss jabs could prevent and treat addiction to alcohol, cigarettes and drugs, according to a large study. Experts believe the way the medicines work on the brain’s reward pathway cuts cravings ...

Addiction is one of the most common and consequential chronic medical conditions in the United States. Nationwide, more than 46 million people met the criteria for a substance abuse disorder as of ...

New research suggests the weight-loss medications could be powerful tools in tackling substance use disorders.

Al-Aly and his colleagues found that people starting the GLP-1 drugs had lower risks of developing addiction to multiple ...

Remarkable scientific progress over the past five decades has helped us develop knowledge of how drugs of abuse induce pleasure, reinforce use, and lead to the compulsive self-administration we call ...

A popular class of drugs for treating diabetes and obesity reduces addiction, including abuse of alcohol, tobacco, cannabis, ...

People struggling with many addictions, ranging from opioids to gambling, are reporting similar experiences in clinics, on ...