A novel study using a mouse model has found that the absence of the angiopoietin-like 4 (ANGPTL4) protein during development ...

Age-related memory decline and neurodegenerative diseases like Alzheimer's are often thought of as irreversible. But the brain is not static; neurons continually adjust the strength of their ...

The capacity of an organism to regenerate depends on cell dedifferentiation followed by proliferation. Mammals, in general, have limited regenerative capacity. Now, a team of researchers at the Salk ...

Cells of a multicellular organism are functionally heterogeneous owing to the differential expression of genes. Historically, differential gene expression had been thought to involve the genetic ...

It is well known that adding a mixture of four reprogramming molecules (Oct4, Sox2, Klf4 and c-Myc) also known as “Yamanaka factors” to cells can reset epigenetic marks to their original patterns.

Stimulating a key metabolic pathway in T cells can make them work more effectively against tumors when combined with immune checkpoint inhibitor therapy, according to a preclinical study. The findings ...

Abnormalities in the TME contribute to immunosuppression and dictate the outcome of various immunotherapeutic approaches. Reprogramming specific facets of the immune compartment, such as ...

Two teams of researchers have developed a cell reprogramming technology that converts rogue disease-causing T cells from our immune system into protective T reg cells. These cells help ensure that the ...

For those hoping to cure death, and they are legion, a 2016 experiment at the Salk Institute for Biological Studies in San ...